This study explores clinicians’ perspectives regarding the delivery of tobacco cessation services to cannabis users, elucidating systemic barriers, intervention types, and organizational challenges. Conducted in Catalonia, Spain, it highlighted three major themes: high co-use prevalence, clinician beliefs influencing co-use, and integrated harm-reduction strategies into substance use programs. Results emphasize the need for tailored approaches, clinician training, and reduced fragmentation of care to improve treatment outcomes. This research highlights the importance of collaboration across clinicians, researchers, and policymakers to create practical, comprehensive responses to co-existing cannabis and tobacco use that can lead to better public health outcomes.