cendoc bogani publicaciones PMD conductas adictivas

Fitxa Bibliografía científica

Novel halogenated synthetic cannabinoids impair sensorimotor functions in mice

Bilel, Sabrine; Tirri, Micaela; Arfe, Raffaella; Ossato, Andrea; Trapella, Claudio; Serpelloni, Giovanni; Neri, Margherita; Fattore, Liana; Marti, Matteo

Any: 2020

JWH-018-C1, JWH-018-Br and AM-2201 (JWH-018 halogenated-derivatives; JWH-018-R compounds) are synthetic cannabinoid agonists illegally marketed as "Spice", "K2", "herbal blend" and research chemicals for their cannabis-like psychoactive effects. In rodents, JWH-018 and its halogenated derivatives reproduce the typical effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), i.e. hypothermia, analgesia, hypolocomotion and akinesia. Yet, the effects of JWH-018-R compounds on sensorimotor functions are still unknown. This study was designed to investigate the effect of an acute intraperitoneal (i.p.) administration of JWH-018-R compounds (0.01-6 mg/kg) on sensorimotor functions in mice and to compare them to those caused by the reference compound JWH-018 and Delta(9)-THC. A well validated battery of behavioral tests was used to investigate the effects of these synthetic cannabinoids on the visual, auditory and tactile responses in mice, while the pre-pulse inhibition (PPI) test was used to investigate their effect on sensorimotor gating. The effect of the synthetic cannabinoids on spontaneous locomotion was also measured by a video tracking analysis to assess potential cannabinoid-induced motor impairment. Results showed that, similarly to JWH-018, systemic administration of JWH-018-R compounds inhibits sensorimotor and PPI responses at lower doses (0.01-0.1 mg/kg) and reduced spontaneous locomotion at intermediate/high doses (1-6 mg/kg). All effects were prevented by the administration of the selective cannabinoid CB1 receptor antagonist/inverse agonist AM-251 thus confirming a CB1 receptor-mediated action. Finding that lower doses of JWH-018-R compounds selectively impair sensorimotor and PPI responses without affecting locomotion should be carefully considered to better understand the potential danger that halogenated-derivatives of JWH-018 may pose to public health, with particular reference to decreased performance in driving and hazardous works.

Tipo document:

Artículo

Número/Volum:

76

Pàgines:

17-32

Font:

NEUROTOXICOLOGY

Paraules clau:

JWH-018-CI; JWH-018-Br; AM-2201; Sensorimotor responses; Synthetic cannabinoids; Prepulse inhibition

 

Comparteix amb altres persones

Compateix Compateix  Compateix

Concejalía de Servicios Sociales de l´Ajuntament de València

Logotipo Universitat de València
Logotipo UISYS
Logotipo CSIC
Logotipo Consellería de Sanitat de la Generalitat Valenciana

Segueix-nos a:

 

Darrera actualització: 28/03/2024

Centre de documentació sobre drogodependències i altres trastorns addictius Dr. Emilio Bogani Miquel
Cendoc Bogani

Publicacions, Articles, Cartells, Posters i enllaços Web sobre Drogodependències i Trastorns Addictius rellevants per a professionals de les Ciències de la Salut, Educació e Informació.

Copyright © Centro de documentación sobre drogodependencias y otros trastornos adictivos Dr. Emilio Bogani Miquel, 2019.
Cendoc Bogani - C/ Amadeo de Saboya, 11 - bajo - 46010 - Valencia
Utilitzem cookies pròpies i de tercers per a millorar els nostres serveis i amb finalitats estadístics. En continuar amb la navegació entenem que s'accepta la nostra política de cookies. Més Informació