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Design of a randomized controlled trial to Link Infectious and Narcology Care (LINC-II) in St. Petersburg, Russia

Gnatienko, Natalia; Lioznov, Dmitry; Raj, Anita; Blokhina, Elena; Rosen, Sydney; Cheng, Debbie M.; Lunze, Karsten; Bendiks, Sally; Truong, Ve; Bushara, Natalia; Toussova, Olga; Quinn, Emily; Krupitsky, Evgeny; Samet, Jeffrey H.

Año: 2020

Background If Russia is to achieve the UNAIDS 90-90-90 HIV targets, better approaches to engage, effectively treat, and retain patients in care are needed. This paper describes the protocol of a randomized controlled trial (RCT) testing the effectiveness of LINC-II, a strength-based case management program for HIV-positive people who inject drugs (PWID) to increase rates of HIV viral suppression, ART initiation, and opioid abstinence. Methods This RCT will enroll and randomize 240 participants, recruited from a narcology (addiction care) hospital in St. Petersburg, Russia. Participants are randomized to the intervention or control arms. Those in the intervention arm receive: (1) strengths-based HIV case management supporting coordinated care; (2) rapid ART initiation; and (3) pharmacotherapy for opioid use disorder. We will evaluate the intervention´s effectiveness compared to standard of care on the following outcomes: (1) undetectable HIV viral load at 12 months (primary); (2) initiation of ART within 28 days of randomization; (3) change in CD4 count from baseline to 12 months; (4) retention in HIV care (i.e., >= 1 visit to medical care in 2 consecutive 6 month periods); (5) undetectable HIV viral load at 6 months; and (6) past 30-day opioid abstinence (at 6 and at 12 months). Discussion This RCT will assess the LINC-II intervention in an urban Russian setting. If effective, it will offer a new approach for increasing the uptake of both HIV and opioid use disorder treatment and coordination of these modalities in standard Eastern European clinical settings.

Tipo documento:

Artículo

Número/Volumen:

15

Páginas:

0 - 0

Fuente:

ADDICTION SCIENCE & CLINICAL PRACTICE

Palabras clave:

HIV; PWID; Case management; Rapid ART; Naltrexone

 

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Última actualización: 06/08/2020

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